Endocrine Abstracts

Orexin-A are newly described family of orexigenic hypothalamic neuropeptides. The distribution of orexin immunoreactive fibers overlaps with the LHRH neuronal system in the septo-preoptic area and the arcuate nucleus-median eminence region. However, the actual role of the orexinergic system in the timing of puberty onset remains unexplored. The aim of the present study was to assess, in immature female and male rats, the effect of the orexinergic system on the reproductive axi...